Management

If You Are Rh Negative

Choose a preferred language

If you are pregnant and your blood is Rh negative, you need to be treated with medicine. You need this treatment even if you miscarry or don’t deliver the baby. This is to protect the health of any baby you have in the future.


What is the treatment?

The treatment is a shot of medicine. The medicine is called Rho(D) immune globulin. This stops Rh antibodies from forming. The shot won’t harm you or your baby.


When are you treated?

If your blood has not made Rh antibodies, you’ll be given the medicine at these times:

  • During week 28 of your pregnancy

  • Any time there’s a chance that your baby's blood has mixed with yours (such as due to a miscarriage or an ectopic pregnancy)

  • If you have a prenatal test called amniocentesis

  • If you have vaginal bleeding before 28 weeks

Healthcare provider giving woman injection in arm.


After you give birth

After you give birth, your baby’s blood will be tested. If their blood is Rh positive, you’ll be given the medicine again in 3 days. If their blood is Rh negative, you won’t need the medicine until your next pregnancy.


If you already have Rh antibodies

If your blood has antibodies, this is called Rh sensitization. Rho(D) immune globulin can’t protect the baby. You and your baby will need special care during pregnancy. This may include extra tests. Your healthcare provider will tell you what to expect.


Preventing future problems

Your risk of making Rh antibodies rises with each pregnancy. This is true even if you don’t deliver a baby. Your body can make Rh antibodies even if you don’t give birth. This includes if you have an ectopic pregnancy. This is when the fertilized egg is outside the uterus. It's true for a pregnancy that ends in miscarriage or abortion. You will still need the Rho(D) immune globulin medicine. This is to prevent problems in any future pregnancy.

Featured in

Online Medical Reviewer: Donna Freeborn PhD CNM FNP

Online Medical Reviewer: Heather M Trevino BSN RNC

Online Medical Reviewer: Irina Burd MD PhD

© 2000-2026 The StayWell Company, LLC. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.
Suitcase Icon

Learn More About Health Services at PIH Health

Expert care for every stage of life. Explore the comprehensive services offered at PIH Health.

Explore Services
Newspaper Icon

Get Health Tips & Updates

Sign up for helpful health information, wellness tips and news from PIH Health, delivered straight to your inbox.

Subscribe
Related Articles
Read article
OB/GYN
Back Pain During Pregnancy: Moving Safely

Learning the correct ways to bend, lift, and carry objects may help relieve back strain. It will also help you protect your back after your baby is born. Remember, if you’re having trouble protecting your back, it’s OK to ask the people around you for help!

Read article
OB/GYN
Folic Acid for a Healthy Baby

Getting enough folic acid can reduce the risk for neural tube defects (NTDs) and may also reduce the risk for other serious birth defects of the brain and spinal cord.

Read article
OB/GYN
Adapting to Pregnancy: Second Trimester

Keep up the healthy habits you started in your first trimester. You might be a little more tired than normal. So plan your day wisely. Look at the tips below and choose the ones that suit your lifestyle.

Read article
OB/GYN
Alcohol and Pregnancy

Drinking alcohol while pregnant is a leading cause of birth defects in a baby. In addition, the risk for miscarriage and stillbirth increases with alcohol consumption. Read on to learn more.

Stethoscope Icon

Personalized Care Starts with the Right Provider

Search by specialty, location, and more.

Find A Doctor
Appointments Icon

Make an Appointment

Your health can't always wait. Schedule an appointment with a PIH Health provider.

Schedule an Appointment
Cross Icon

Find a PIH Health Urgent Care Location

Need care today?. Find the nearest PIH Health Urgent Care location.

Find Urgent Care